Taurolidine citrate and unfractionated heparin combination versus unfractionated heparin alone in prevention of inflammation in hemodialysis catheters

Abstract

All patients were subjected to full history taking with special highlight on: (age, gender, etiology of ESRD, hemodialysis duration). CBC, hsCRP, IL-6 were measured at the start and after one month of catheter insertion.in addition to cultures when CRBSI is suspected. Blood flow rate, URR were measured weekly in both groups to assess catheter performance. On comparison between both groups as regard levels of inflammatory markers before and after one month of catheter insertion, we found a significant difference in favor of group 1 indicating lower levels of inflammation. Our results also showed a better catheter performance in group 1 that was proved by better blood flow measured over dialysis sessions in association with better results for URR, a significant drop in values of blood flow and URR from 1st to 4th week was observed in group 2 with classic heparin lock.