"Association of CTRP and chemokine ligand-2 in Egyptian diabetic women with or without CAD"

Abstract

Type 2 diabetes and obesity are considered global epidemics with worldwide social problems. In addition, they cause an array of disorders as HTN, atherosclerosis and CAD. Women, in particular postmenopausal females, are prone to CAD due to lack of female cardio-protective hormones as well as higher fat content and distribution in comparison to males. Adipocytes are important endocrine cells, which secrete several hormones, inflammatory markers, and cytokines. These inflammatory markers and cytokines are involved in whole body hemostasis and in turn several metabolic disorders such as T2D, obesity, low grade inflammation, and CAD. Where, AT is seen as a central driver for these metabolic disorders, a lot of efforts have been made to delineate the relationship between obesity, DM and their complications, however it is still far from full comprehension. Among the huge continuously growing number of discovered adipokines, the CTRP super family has emerged as novel adipocytokines, with important physiological and metabolic roles specifically, CTRP3 and CTRP9. However, their role in postmenopausal females with or without T2D and with or without CAD is still controversial.