Facilitatory Effects of Perineural Dexmedetomidine on Neuraxial and Peripheral Nerve Block
Mennatullah Mohamed Sobhy;
Abstract
ABSTRACT
Background: DXM is an anxiety reducing, sedative, and pain medication. It has been used as adjunct to local anesthetics to improve the quality of perioperative analgesia and prolong its duration. Alpha2-adrenergic agonists have expanded the horizons of regional anesthesia. DXM is a highly selective α-2 agonist similar to clonidine but with a greater affinity for the α-2 receptor. It is the pharmacologically active d-isomer of medetomidine, a full agonist of α-2 adrenergic receptors.
Objective: The aim of this study is to evaluate the efficacy of DXM as an adjuvant to local anesthetics for intrathecal and supraclavicular blocks compared to LA alone.
Background: DXM is an anxiety reducing, sedative, and pain medication. It has been used as adjunct to local anesthetics to improve the quality of perioperative analgesia and prolong its duration. Alpha2-adrenergic agonists have expanded the horizons of regional anesthesia. DXM is a highly selective α-2 agonist similar to clonidine but with a greater affinity for the α-2 receptor. It is the pharmacologically active d-isomer of medetomidine, a full agonist of α-2 adrenergic receptors.
Objective: The aim of this study is to evaluate the efficacy of DXM as an adjuvant to local anesthetics for intrathecal and supraclavicular blocks compared to LA alone.
Other data
| Title | Facilitatory Effects of Perineural Dexmedetomidine on Neuraxial and Peripheral Nerve Block | Other Titles | الآثار التسهيلية لديكسميديتوميدين كمخدر موضعي مساعد لمخدرات الأعصاب الطرفية والجهاز العصبي المركزي | Authors | Mennatullah Mohamed Sobhy | Issue Date | 2019 |
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