Protective Role of Antioxidants in Breast Cancer

Abstract

Summary: In the present study, the antioxidant activities of glutathi9ne peroxidase (OPX) and supcroxidc dismutasc(SOD) in erythrocytes and their cofactors zinc and selenium in serum were measured in 50 cases with cilnc.cr breast. 50 cases with metastatic cancer breast and SO cases as norm:tl.controi.S to lind if there is any relation between the level of glutathione peroxidase. supcroxidc dismutase, scleniumand zinc and cancer breast, metastatic cancer breast and the normal control ca es. The patients were collected from the National Cancer fnstitutC.

Our results showed that the mean of glutathione peroxidasc(OPX) was significantly lower in both breast cancer patients with and without metastasis, compared with the control group; •

Serum selenium levels showed a significant decrease in breast cancer patients With and without metastasis, compared with controls.

The mean level of red cells superoxidc di.smuiasc(SOD) in breast cancer was found to be insignificantly lower than that of the control subjects. However the mean level of supcroxide dismutase SOD in metastatic breast cancer was found to be significantly lower, compared with the control subjects.

Also, it was found that the mean level Of zinc in breast cancer pntieOts was insignificantly lower comp.1rcd with the control subjects, while in patients. with metastatic breast cancer, the mean level of zinc was significnntly lower compared with the control subjects.