Preparation and Characterization of Calcium Silicate Ceramic Doped with Manganese for Bone Treatment

Abstract

Bone infection is the main source that triggers and initiates osteomyelitis. The patient suffering from such a brutal bone disease is usually subjected to long-term antibiotic treatment, which can lead to acute toxicity to other parts of body. To offer a solution for such condition, several materials scientists have designed localized targeting devices that can release controlled therapeutic doses of antibiotic directly at infected site, which maximize the benefit of treatment and reduce the toxic effect of the drug. Also, the removal of necrotic bone by surgeon creates large bone defects that need a bioactive material to regenerate and augment that defect.