Acyl Ghrelin Levels in Autistic Males
Hanan Mohamed Abozaied;
Abstract
A
SD is a neurodevelopmental disorder for which not only no exact cause has been identified but also no definitive cure has been found yet. Its prevalence has dramatic rise (1in 68 individuals).
ASD is characterized by persistent impairment of social interaction, deficits in verbal and non-verbal communication, and restricted repetitive and stereo-typed patterns of behavior and interests (DSM-5).
There is decrease in acylghrelin, des acylghrelin and growth hormone(GH) levels in autistic children in comparison with age matched control group. This is the first study in Egypt in which ghrelin was measured in autistic children. Owing to ghrelin capacity to affect neuroinflammatory and apoptotic processes that were shown to be linked to autism, a potential role for ghrelin in the pathogenesis of autism is considered and further studies are needed to elucidate the role of ghrelin as a diagnostic marker and a potential therapeutic agent in autism. This study is also aimed to further elucidate the associated hormonal dysregulation.
SD is a neurodevelopmental disorder for which not only no exact cause has been identified but also no definitive cure has been found yet. Its prevalence has dramatic rise (1in 68 individuals).
ASD is characterized by persistent impairment of social interaction, deficits in verbal and non-verbal communication, and restricted repetitive and stereo-typed patterns of behavior and interests (DSM-5).
There is decrease in acylghrelin, des acylghrelin and growth hormone(GH) levels in autistic children in comparison with age matched control group. This is the first study in Egypt in which ghrelin was measured in autistic children. Owing to ghrelin capacity to affect neuroinflammatory and apoptotic processes that were shown to be linked to autism, a potential role for ghrelin in the pathogenesis of autism is considered and further studies are needed to elucidate the role of ghrelin as a diagnostic marker and a potential therapeutic agent in autism. This study is also aimed to further elucidate the associated hormonal dysregulation.
Other data
| Title | Acyl Ghrelin Levels in Autistic Males | Other Titles | دراسة مستوي الأثيل غريلين في الأطفال المصابين بمرض التوحد | Authors | Hanan Mohamed Abozaied | Issue Date | 2019 |
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