Long Term Hepatic Histopathological Outcome in Wilson's Disease
Shaimaa Ibrahim Abdel Baset Kotb;
Abstract
ABSTRACT
Background: Hepatic dysfunction in Wilson’s disease may assume several forms. Asymptomatic enlargement of the liver and spleen may occur, sometimes with elevation of liver enzymes. Acute transient hepatitis is the mode of presentation of those in whom hepatic symptoms herald disease onset. Although this may be mistaken for viral hepatitis by the unwary, the presence of hemolytic anemia in conjunction with the hepatic dysfunction, or elevation of unconjugated (indirect) bilirubin, should alert the clinician to the possibility of Wilson’s disease.
Objective: To determine the long term outcome and progression of the hepatic histopathology in two liver biopsies from patients with wilson's disease under treatment. comparing liver biopsy done at the diagnosis and another one at least 3 years later and correlate it with the clinical outcome.
Background: Hepatic dysfunction in Wilson’s disease may assume several forms. Asymptomatic enlargement of the liver and spleen may occur, sometimes with elevation of liver enzymes. Acute transient hepatitis is the mode of presentation of those in whom hepatic symptoms herald disease onset. Although this may be mistaken for viral hepatitis by the unwary, the presence of hemolytic anemia in conjunction with the hepatic dysfunction, or elevation of unconjugated (indirect) bilirubin, should alert the clinician to the possibility of Wilson’s disease.
Objective: To determine the long term outcome and progression of the hepatic histopathology in two liver biopsies from patients with wilson's disease under treatment. comparing liver biopsy done at the diagnosis and another one at least 3 years later and correlate it with the clinical outcome.
Other data
| Title | Long Term Hepatic Histopathological Outcome in Wilson's Disease | Other Titles | التغيرات الكبدية الهستوباثولوجيه التي تحدث علي المدي الطويل في مرض ويلسون | Authors | Shaimaa Ibrahim Abdel Baset Kotb | Issue Date | 2019 |
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