Circulating CD4+CD28null T cells and its Association with Atherosclerotic Changes in Patients with End Stage Renal Disease

Abstract

Patients with ESRD, including those on HD, have a high risk for cardiovascular and atherosclerotic diseases. As traditional risk factors cannot alone explain the unacceptable high prevalence and incidence of CVD in this population, inflammation and other non-traditional risk factors may contribute. The aim of the current study was to investigate association between peripheral CD4+CD28null T cells population and early atherosclerotic damage in ESRD patients on HD. The CRP was significantly higher in ESRD patients with atherosclerotic changes compared to the other two studied groups. Qualitative laboratory assays in the three studied groups reveals that patients with both positive CMV IgG and CRP were significantly higher in the ESRD group with atherosclerotic changes compared to the other two studied groups.