THE EFFECT OF DAILY HEMODIALYSIS ON NEUROMUSCULAR FUNCTION

Abstract

The uremic syndrome is characterized by overall deterioration of biochemical and physiological functions in parallel with the progression of renal failure. Despite the beneficial effects of hemodialysis, uremic polyneu'ropathy represents a well-known complication of end-stage renal failure (ESRF). It should be regarded as an indicator of the degree of renal failure and its control by hemodialysis. During renal failure, muscle weakness may develop. The pathogenesis of uremic neuropathy has. been proved to be caused by major neurotoxins accumulating in uremia such as urea, creatinine, uric acid, middle molecules and others. Those uremic toxins can be cleared by different dialytic techniques which vary widely depending on duration, membrane, and blood and dialysate flow rates. Recent attention is paid to the precious role of daily dialysis in improving the patients clinically and biochemically. In this work, we studied 20 patients on chronic hemodialysis programme. All patients showed the criteria of end-stage renal failure (ESRF).