Nanosized Delivery Systems for Radiopharmaceuticals
Moamen Mohamed Soliman Mohamed;
Abstract
The present study is divided into three parts:
The first part: Preparation of Poly ethylene oxide-Poly acrylic acid (PEO- PAAc) nanogel and Poly ethylene oxide-Poly
acrylic acid/ conjugated with Folic acid (PEO-PAAc)/FA.
99mTc.
The second part: Radiolabeling of PEO-PAAc / FA with
The third part: In vivo biodistribution of 99mTc-PEO- PAAc/FA complex in normal mice after intravenous injection and in solid tumour bearing mice after intravenous and intratumor injection.
Results can be summarized as follow:
The first part: Preparation of Poly ethylene oxide-Poly acrylic acid (PEO- PAAc) nanogel and Poly ethylene oxide-Poly acrylic acid/Folic acid conjugate PEO-PAAc/FA:
1- PEO-PAAc was prepared via gamma radiation induced polymerization and crosslinked network.
2- There are some factors that control the size of the prepared nanogel such as: the polymer feed composition,
The first part: Preparation of Poly ethylene oxide-Poly acrylic acid (PEO- PAAc) nanogel and Poly ethylene oxide-Poly
acrylic acid/ conjugated with Folic acid (PEO-PAAc)/FA.
99mTc.
The second part: Radiolabeling of PEO-PAAc / FA with
The third part: In vivo biodistribution of 99mTc-PEO- PAAc/FA complex in normal mice after intravenous injection and in solid tumour bearing mice after intravenous and intratumor injection.
Results can be summarized as follow:
The first part: Preparation of Poly ethylene oxide-Poly acrylic acid (PEO- PAAc) nanogel and Poly ethylene oxide-Poly acrylic acid/Folic acid conjugate PEO-PAAc/FA:
1- PEO-PAAc was prepared via gamma radiation induced polymerization and crosslinked network.
2- There are some factors that control the size of the prepared nanogel such as: the polymer feed composition,
Other data
| Title | Nanosized Delivery Systems for Radiopharmaceuticals | Other Titles | أنظمة التوصيل النانوية الحجم للمستحضرات الصيدلانية المشعة | Authors | Moamen Mohamed Soliman Mohamed | Issue Date | 2019 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| cc1032.pdf | 894.81 kB | Adobe PDF | View/Open |
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