Formulation And Evaluation Of Some Medicated Polymeric Topical Films

Abstract

lncorporation of drugs into inert polymeric films during their manufacture affords a possible method of achieving controlled release.• Such products can be adapted to be topical, oral and other routes of administration by utilizing them directly or in the form of coating films. Drug release may be altered by variations of the dimensioi1al parameters of the film, the polymeric matrix material and the concentration in the film. lnert and insoluble matrices of plastic natures were shown to exhibit time-dependent release profiles. Dermatological films was reported to be preferable when compared to ointments or creams due to the following reasons: (i) Releasing drugs in a sustained profile over a reasonable time. ' (ii) Flexibility of the dose included in the film.

(iii) asy to terminate therapy by removing the film.

Selection of the best film composition for any particular use requires studying the mechanical properties of the film, the moisture absorption and drug release.•

i Tetracaine hydrochloride is a local <1nesthetic of ester-type used . topically on the eye, in the nose or throat and by infiltration for subarachnoid block (spinal analgesia). It is available in various topical formulations. It has. a short duration of action and frequent applications are usually required. On this basis, we can formulate tetracaine hydrochloride in polymeric films, which may control the drug delivery over a reasonable period of time.