Evaluation of Blood Neutrophil Lymphocyte Ratio (NLR) & Platelet Lymphocyte Ratio (PLR) As Inflammatory Biomarkers in Childhood Asthma

Abstract

ABSTRACT Background: It is shown that neutrophil to lymphocyte ratio (NLR) as an indicator of inflammation) measured in peripheral blood has a contribution in the determination of diagnosis and prognosis in numerous diseases. This study investigated the correlation between asthma control status and NLR in asthmatic children and asthma phenotypes according to their sputum cytology. Patients and Methods: a Case control study on 60 asthmatic children, 10healthy subjects were included in the study. Respiratory function tests (RFT) was applied to the patients. Level of control was assessed with the asthma control questionnaire (ACQ). The difference between patients groups and control groups in terms of NLR was examined. Results: The median NLR was 1.32 (1.12-1.6) in the patient group and 0.71 (0.4425-1.125) in the control group. The difference was statistically highly significant (p=0.003). Also, median NLR was 1.32 (1.12-1.6) in the patient group and 0.71 (0.4425-1.125) in the control group.