Role of Intralipid for Women with Idiopathic Recurrent Miscarriage and Raised Levels of Uterine Natural Killer (uNK) Cells in the Endometrium

Abstract

In 50% of all conceptions fail (most unrecognized), 13-15% of recognized pregnancies are lost, 90 % of these before 12-14 weeks . Unexplained Recurrent pregnancy loss is a stressful condition for both patients and clinicians. Despite wide range of investigations. Various studies have been performed to discover the causes of RPL, among them raised NK cells have been considered as one of the important causes in several studies. The purpose of this study was to investigate if IV intralipid 20% can increase rate of live birth in women with raised NK cells. This was a randomized doubly blinded controlled study of 200 women with unexplained RPL who underwent endometrial immunohistochemical studies and shows raised level of uNK and was given IV intralipid 20% in RPL clinic of Ain Shams University Hospital. Before beginning treatment with IV intralipid, endometrial sample have been taken mid luteal and was analyzed revealing raised level of uNK cells ≥5% of stromal cell.