Preparation of 99Mo/99m Tc Generator and Labeling of Some Organic Compounds with Technetium-99m

Abstract

The first chapter includes the theoretical definitions and considerations of the subject. The introductory chapter contains the overview of the radionuclides and their importance in the fields of chemistry, agriculture and diagnostic nuclear medicine, their energies, decay mode, half lives and their uses. The importance and advantages of technetium, the physical and chemical properties of molybdenum and the radioisotopes of molybdenum their half-lives, radiochemistry of technetium radioisotopes. Production of molybdenum as a parent for technetium in the reactor and cyclotron. A brief information on the transient equilibrium growth kinetics for the 99Mo/99mTc generator, types of 99Mo/99mTc generators such as Solvent extraction, sublimation, electrochemical and chromatographic generators. The previous literatures on gel generator technique and their bed materials. The labeling methods with technetium-99m were also included. Short and brief account on the quality control of the technetium-99m eluate and for determining the radiochemical yield for 99mTc-complexes.