COMPARATIVE STUDY BETWEEN THE EFFECT OF SOME HEPATIC PROTECTOR DRUGS ON PROGNOSIS OF HEPATIC DISORDERS
Amany Abdel-Rahim Ahmed Abdin;
Abstract
It is emphasized that oxidative damage could be a consequence of tissue injury or as a cause of it (Halliwell,1994 ).
The generation of reactive free radicals reduce the antioxidant defenses in the liver through stimulation of lipid peroxidation which has been implicated in a wide variety of hepatic injuries and diseases ( Ross & Moldeus,1991 ).
A great d al of interest focuses on the mechanisms whereby the antioxidant agents can prevent or decrease the potentially harmful radical reactions ( Sies & Krinsky,1995 ).
Vitamin E ( Reynolds,1996 b* ) , vitamin A ( Cahill et a!.,1993 ) , and silymarin ( Flora et a!.,1998 ) are considered to have antioxidant activity , thus may play a valuable role in cellular defense in the liver.
Hopefully , this realization will contribute to the development of new preventive and therapeutic strategies of liver disorders ( Halliwell,1994 ).
A particular area of interest in pharmacology is the possibility that the side effects of several drugs involve increased oxidative damage ( Aust et a!.,1993 ).
Drug-induced hepatotoxicity , e.g. acetaminophen , is shown to increase lipid peroxidation ( Reiter & Wendel,1983 ).
Also , hepatic schistosomiasis causes damage and fibrosis of the liver by an oxidative mechanisms ( Pincus et a!.,1981 and Bissell et a!.,1990).
The aim of this work is to evaluate the role of vitamin E , vitamin A , and silymarin (as antioxidants) on prognosis of acetaminophen-induced hepatotoxicity and experimentally-induced hepatic fibrosis by schistosoma mansoni infection in mice. The study evaluates their effects on hepatic lipid peroxides level , liver function tests ( including SGPT; SGOT; prothrombin time & activity; total bilirubin; and albumin level ) , and lastly the histopathological changes occurring in the liver of mice.
In this work we used 233 albino mice , weighing 20-40 g. The mice were caged under the same conditions as regard food and drink in easy access all over the period of the work. They were divided into the following groups :
(1) Control (normal) group :
The mice were administered distilled water and olive oil orally.
The generation of reactive free radicals reduce the antioxidant defenses in the liver through stimulation of lipid peroxidation which has been implicated in a wide variety of hepatic injuries and diseases ( Ross & Moldeus,1991 ).
A great d al of interest focuses on the mechanisms whereby the antioxidant agents can prevent or decrease the potentially harmful radical reactions ( Sies & Krinsky,1995 ).
Vitamin E ( Reynolds,1996 b* ) , vitamin A ( Cahill et a!.,1993 ) , and silymarin ( Flora et a!.,1998 ) are considered to have antioxidant activity , thus may play a valuable role in cellular defense in the liver.
Hopefully , this realization will contribute to the development of new preventive and therapeutic strategies of liver disorders ( Halliwell,1994 ).
A particular area of interest in pharmacology is the possibility that the side effects of several drugs involve increased oxidative damage ( Aust et a!.,1993 ).
Drug-induced hepatotoxicity , e.g. acetaminophen , is shown to increase lipid peroxidation ( Reiter & Wendel,1983 ).
Also , hepatic schistosomiasis causes damage and fibrosis of the liver by an oxidative mechanisms ( Pincus et a!.,1981 and Bissell et a!.,1990).
The aim of this work is to evaluate the role of vitamin E , vitamin A , and silymarin (as antioxidants) on prognosis of acetaminophen-induced hepatotoxicity and experimentally-induced hepatic fibrosis by schistosoma mansoni infection in mice. The study evaluates their effects on hepatic lipid peroxides level , liver function tests ( including SGPT; SGOT; prothrombin time & activity; total bilirubin; and albumin level ) , and lastly the histopathological changes occurring in the liver of mice.
In this work we used 233 albino mice , weighing 20-40 g. The mice were caged under the same conditions as regard food and drink in easy access all over the period of the work. They were divided into the following groups :
(1) Control (normal) group :
The mice were administered distilled water and olive oil orally.
Other data
| Title | COMPARATIVE STUDY BETWEEN THE EFFECT OF SOME HEPATIC PROTECTOR DRUGS ON PROGNOSIS OF HEPATIC DISORDERS | Other Titles | دراسة مقارنة مقارنة بين تأثير بعض الأدوية الواقية للكبد على تطور اضطرابات الكبد | Authors | Amany Abdel-Rahim Ahmed Abdin | Issue Date | 2003 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B13713.pdf | 1.04 MB | Adobe PDF | View/Open |
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