PLASMINOGEN ACTIVATOR INHIBITOR AS A MEASURE OF REPERFUSION IN Acute myocardial infarction In diabetics
Hassan Hussein Abou Hatab;
Abstract
In diabetic patients mortality and morbidity from AMI are high. Certain risk factors for myocardial infarction have been linked with disturbances in fibrinolytic activity.
The objective of this study was to estimate activity of PAI-l in diabetic as compared with non-diabetic patients admitted with AMI and to determine whether PAI-1 activity influences reperfusion after thrombolytic therapy.
Reperfusion was assessed by time to peak release of CKMB levels and by ST-segment elevation resolution.
234 patients admitted to CCU Queen Elizabeth Hospital, Birmingham, UK with AMI were eligible for the study if they had chest pain accompanied by ST-segment elevation, if they are admitted within
12 hours from the onset of pain. Only one hundred patients completed the study after implementing the exclusion criteria.
The patients ages ranged from 37-78 years with a mean of 56 ± 8.2 years in diabetic and 59 ± 8.7 years in non-diabetic patients. There were 53 male and 47 female patients. They were categorized into two groups: Diabetic group consisted of 38 patients, 28 were previously diagnosed as having diabetes and 10 were newly diagnosed on the basis of elevated random blood sugar and HbAtc levels.
The objective of this study was to estimate activity of PAI-l in diabetic as compared with non-diabetic patients admitted with AMI and to determine whether PAI-1 activity influences reperfusion after thrombolytic therapy.
Reperfusion was assessed by time to peak release of CKMB levels and by ST-segment elevation resolution.
234 patients admitted to CCU Queen Elizabeth Hospital, Birmingham, UK with AMI were eligible for the study if they had chest pain accompanied by ST-segment elevation, if they are admitted within
12 hours from the onset of pain. Only one hundred patients completed the study after implementing the exclusion criteria.
The patients ages ranged from 37-78 years with a mean of 56 ± 8.2 years in diabetic and 59 ± 8.7 years in non-diabetic patients. There were 53 male and 47 female patients. They were categorized into two groups: Diabetic group consisted of 38 patients, 28 were previously diagnosed as having diabetes and 10 were newly diagnosed on the basis of elevated random blood sugar and HbAtc levels.
Other data
| Title | PLASMINOGEN ACTIVATOR INHIBITOR AS A MEASURE OF REPERFUSION IN Acute myocardial infarction In diabetics | Other Titles | دراسة العامل المثبط لنشاط البلازمينوجين في مرضى السكر المصابين باحتشاء في عضلة القلب | Authors | Hassan Hussein Abou Hatab | Issue Date | 2003 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B13714.pdf | 1.01 MB | Adobe PDF | View/Open |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.