Comparative Analytical and Stability Studies of Certain FDA Approved Antibacterial Drugs

Abstract

The work completed during the preparation of this thesis was done to develop new analytical methods for the determination of some ,. antibacterial drugs. These drugs are Norfloxacin in the presence of

Tinidazole, Acediasulfone in the presence of Cinchocaine, Cefuroxime, Minocycline and Neomycin. The thesis is presented in six sections

Section one: introduction

A classification of antibacterial drugs Is presented with a brief explanation of their mechanisms of action. A literature survey for the official and reported methods for quantitative determination of the selected drugs in concern is given. Section two: Aim and basis of the work

The aim of this work and the basis on which the proposed methods were chosen is clarified. Section three: Experimental, Results and Discussion

. Part I Determination of Norfloxacin in the presence of Tinidazole This part is divided into 2 categories: a) chromatographic and b) spectrometric methods Part I A Stability indicating chromatographic methods for the determination of Norfloxacin in mixtuure with Tinidazole 1. HPLC method

A HPLC method was developed for the simultaneous determination of Norfloxacin and Tinidazole. The method has a further advantage in the sense that is also a stability indicating, since it is capable of determining the two drugs in the presence ofNorfloxacin decarboxylated degradation product. Optimization of chromatographic conditions is discussed.