SCREENING OF HCV VIRAEMIA IN SEROLOGICALLY NEGATIVE BLOOD DONORS
Amany Hasny Mohamed Abd Elrahman;
Abstract
Infection with hepatitis C v1rus is a matter of great concern because of its potentially grave consequences. HCV infection is extremely common throughout the world, however, its prevalence rate is somewhat puzzling. The highest prevalence rate of HCV infection in the world has been reported among Egyptians (19.2%). In Egypt, schistosoma! liver uisease is significantly associated with HCV infection and genotype 4 is the predominant genotype.
Blood transfusion was thought to be the predominant route of transmission.
Because of the frequency and severity of the disease there was an urgent need to develop direct diagnostic tests for the causative agent, these tests were recombinant based assays for HCV-Ab detection. However, antibody detection methods are of restricted use because there is a mean window period of
22 weeks between infection and seroconversion. Also, despite sensitive antibody-based blood donors screening, a residual risk of transfusion-transmitted viral infection exists.
The detection of HCV-RNA by nucleic acid amplification technique is the method of choice to detect
Blood transfusion was thought to be the predominant route of transmission.
Because of the frequency and severity of the disease there was an urgent need to develop direct diagnostic tests for the causative agent, these tests were recombinant based assays for HCV-Ab detection. However, antibody detection methods are of restricted use because there is a mean window period of
22 weeks between infection and seroconversion. Also, despite sensitive antibody-based blood donors screening, a residual risk of transfusion-transmitted viral infection exists.
The detection of HCV-RNA by nucleic acid amplification technique is the method of choice to detect
Other data
| Title | SCREENING OF HCV VIRAEMIA IN SEROLOGICALLY NEGATIVE BLOOD DONORS | Other Titles | الكشف عن فيروس سى للالتهاب الكبد الوبائى فى العينات السالبة لاختيار المصل للاجسام المضادة للمتبرعين بالدم | Authors | Amany Hasny Mohamed Abd Elrahman | Issue Date | 2002 |
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