Ecofriendly and highly efficient microwaveinduced synthesis of novel quinazolinone-undecyl hybrids with in vitro antitumor activity

Hekal, Mohamed, Fatma S. M. Abu El-Azm, Saad R. Atta-Allah,

Abstract


Novel N-alkyl-quinazolin-4-one derivatives 3–5 were obtained from
reaction of 6-Iodo-2-undecylquinazolin-4(3H)-one (2) with different
alkyl halides. Hydrazinolysis of compound 5 gave the acetohydrazide
6 which reacted with different carbon electrophiles to produce 2-
undecyl-4(3H)-quinazolinone derivatives. The new products were
obtained by either conventional method or by microwave assisting
technique and the structure of all products was confirmed by elemental
and spectral data. The ecofriendly microwave provides an efficiency
over than conventional method in many aspects. All the
synthesized products were tested in vitro against a panel of three
human tumor cell lines, namely, hepatocellular carcinoma (liver)
HepG2, colon cancer HCT-116, and mammary gland breast MCF-7.
Almost all of the tested compounds showed satisfactory activity.


Other data

Title Ecofriendly and highly efficient microwaveinduced synthesis of novel quinazolinone-undecyl hybrids with in vitro antitumor activity
Authors Hekal, Mohamed ; Fatma S. M. Abu El-Azm; Saad R. Atta-Allah
Affiliations Ain Shams University; Ain Shams University; Ain Shams University
Keywords Quinazolinone; 1,3- dioxoisoindoline; isoquinolin- 1,3-dione; antitumor activity; microwave irradiation; benzoxazinone
Issue Date 9-Jul-2019
URI http://hdl.handle.net/123456789/178154
DOI 10.1080/00397911.2019.1637001

Files in This Item:

File Description SizeFormat Existing users please Login
5.pdf1.96 MBAdobe PDF    Request a copy
Recommend this item


Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.