Synthesis and antimicrobial evaluation of the novel heteroannulated furo[3′,2′:6,7]chromeno[2,3-b]pyridines: Part 1
Ibrahim, Magdy; Al-Harbi, S.A. ,; Allehyani, E.S;
Abstract
The chemical behavior of 4,9-dimethoxy-5-oxo-5H-furo[3,2-g]chromene-6-carbonitrile (1) was investigated toward some acyclic and cyclic active methylene ketones namely acetylacetone, ethyl acetoacetate, ethyl benzoylacetate, acetoacetanilide, dimedone, indanedione, pyrazolidine-3,5-dione and 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, barbituric acid and 1-allylthiobarbituric acid, and hippuric acid. A variety of novel heteroannulated furochromenopyridines were efficiently synthesized through a cascade reactions between 4,9-dimethoxy-5-oxo-5H-furo[3,2-g]chromene-6-carbonitrile (1) and the carbon nucleophilic reagents. Structures of the new products were inferred based on their analytical and spectral data.
Other data
| Title | Synthesis and antimicrobial evaluation of the novel heteroannulated furo[3′,2′:6,7]chromeno[2,3-b]pyridines: Part 1 | Authors | Ibrahim, Magdy ; Al-Harbi, S.A. ,; Allehyani, E.S | Keywords | furochromenopyridines | Issue Date | Oct-2020 | Publisher | Wiley | Journal | Journal of Heterocyclic Chemistry | Volume | 57 | Start page | 3632 | End page | 3641 |
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