The Chemical Behavior of (2E)-3-(4,9-Dimethoxy-5-Oxo-5H-Furo[3,2-g] Chromen-6-yl)Acrylonitrile Towards Some Carbon Nucleophiles
Magdy A. Ibrahim; Assiri, M; Ali. T.E; I.S. Yahia; Al-Shimaa Badran;
Abstract
Some novel substituted benzofurans and annulated furochromenes were obtained through the treatment of the novel (2E)-3-(4,9-dimethoxy-5-oxo-5H-furo[3,2-g]chromen-6-yl)acrylonitrile (2) by some active carbon nucleophiles such as active methylene ketones and methylene nitriles. Thus, the reaction of acrylonitrile 2 with acetylacetone, ethyl acetoacetate, diethylmalonate, and acetoacetanilide in ethanol containing piperidine produced efficiently the corresponding polyfunctionalized benzonitrile derivatives 3–5 and furochromeno-pyridine 6, respectively. Also, treatment of acrylonitrile 2 with some methylene nitriles such as malononitrile, ethyl cyanoacetate, and malononitrile dimer afforded the annulated furochromene derivatives 7–9. Furthermore, the pyrido[1,2-a] benzimidazole system 10 was furnished via reaction of acrylonitrile 2 with 2-(1 H-benzimidazol-2-yl)acetonitrile. These reactions took place through Michael addition, retro-Michael, and γ-pyrone ring opening followed by different types of recyclization. The chemical structures of the novel products were established on the basis of their spectral data and elemental analysis.
Other data
Title | The Chemical Behavior of (2E)-3-(4,9-Dimethoxy-5-Oxo-5H-Furo[3,2-g] Chromen-6-yl)Acrylonitrile Towards Some Carbon Nucleophiles | Authors | Magdy A. Ibrahim ; Assiri, M; Ali. T.E; I.S. Yahia; Al-Shimaa Badran | Keywords | ANALOGS;Benzofuran;benzonitrile;carbon nucleophiles;6-formylkhellin;furo[32-g]chromen-6-ylacrylonitrile;recyclization;NATURAL-PRODUCT;DERIVATIVES;PYRIMIDINE;KHELLIN | Issue Date | 2021 | Publisher | Taylor Francis | Journal | Polycyclic Aromatic Compounds | ISSN | 1040-6638 | DOI | 10.1080/10406638.2019.1678181 | Scopus ID | 2-s2.0-85074414175 | Web of science ID | WOS:000491023300001 |
Attached Files
File | Description | Size | Format | |
---|---|---|---|---|
Polycyclic.pdf | 1.52 MB | Unknown | View/Open |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.