Impact of serum soluble programed death ligand 1 on end of treatment metabolic response of diffuse large B cell lymphoma patients

Gadallah, Hoda Ahmed, Kamal, Gihan, Maher, Mohammed Magdy, Mohamad, Mohamad Ayed, El-Ghammaz, Amro M S,

Abstract


Programmed death ligand-1 (PD-L1) plays an important role in the immune evasion of cancer cells and, in turn, can influence the outcome of many malignancies. The serum soluble PD-L1 (sPD-L1) levels were measured in diffuse large B cell lymphoma (DLBCL) patients at diagnosis and at end of treatment. Their impact on end of treatment metabolic response was analyzed. Serum sPD-L1 level was significantly elevated in DLBCL patients at diagnosis than in controls (P < 0.001). Also, serum sPD-L1 level at diagnosis was significantly higher than that at end of treatment (P < 0.001). Patients who achieved partial response (PR) had significantly higher serum sPD-L1 level at end of treatment than controls (P < 0.001). In contrast, all patients especially those who achieved complete response (CR) had insignificantly different serum sPD-L1 level at end of treatment than controls (P = 0.354 and P = 0.090, respectively). There was a significant difference between serum sPD-L1 level at diagnosis and that at end of treatment in patients who achieved PR and CR (P = 0.023 and P < 0.001, respectively). On univariate analysis, presence of comorbidities, Ann Arbor stage IV, high serum sPD-L1 level at diagnosis and high serum sPD-L1 level at end of treatment were significantly associated with achievement of PR (P = 0.018 and P = 0.043, P = 0.045 and P < 0.001, respectively). On multivariate analysis, serum sPD-L1 levels at diagnosis and at end of treatment were still influencing metabolic response significantly (P = 0.014 and P = 0.007, respectively). Serum sPD-L1 is a predictor for metabolic response to immunochemotherapy in DLBCL patients.


Other data

Title Impact of serum soluble programed death ligand 1 on end of treatment metabolic response of diffuse large B cell lymphoma patients
Authors Gadallah, Hoda Ahmed; Kamal, Gihan; Maher, Mohammed Magdy; Mohamad, Mohamad Ayed; El-Ghammaz, Amro M S 
Keywords Diffuse large B cell lymphoma;End of treatment response;Positron emission tomography-computed tomography;Serum soluble programed death ligand 1
Issue Date Nov-2018
Publisher Springer
Journal Clinical and experimental medicine 
Volume 18
Start page 505
End page 512
ISSN 1591-8890
1591-9528
DOI 10.1007/s10238-018-0506-5
PubMed ID 29876769

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