Impact of Additional Chromosomal Aberrations Present at Diagnosis on Outcome of Adolescent and Young Adult Chronic Myeloid Leukemia Patients: A Single Center Experience

El-Ghammaz, Amro, Hamza, Mohamed Tarif, Said, Rasha Magdy, Moussa, Mohamed Mahmoud, Eissa, Asmaa Mohammed Elsayed, Azzazi, Mohamed Osman,

Abstract


Studying the influence of additional chromosomal aberrations (ACAs) present at diagnosis on the outcome of adolescent and young adult (AYA) chronic myeloid leukemia (CML) patients as it has not been addressed previously. Eighty-six AYA CML patients have been analyzed for occurrence of ACAs at diagnosis through performing bone marrow karyotyping. All patients received imatinib mesylate upon diagnosis of CML. Overall response, molecular response, survival status, progression and occurrence of events were monitored during the follow up period. There was a statistically significant difference between patients with and without ACAs regarding overall response (P = 0.049). There was insignificant difference between the two groups regarding achievement of major molecular response (MMR) (P = 0.594), MR4 (P = 0.282) and MR4.5 (P = 0.704). There was a significant difference between patients with and without ACAs regarding time to MMR (P = 0.042) and time to MR4 (P = 0.048) but not regarding time to MR4.5 (P = 0.065). There was insignificant impact of ACAs at diagnosis on overall survival (P = 0.152), progression free survival (P = 0.112), failure free survival (P = 0.114), event free survival (P = 0.194) and alternative treatment free survival (P = 0.731). The presence of ACAs at diagnosis does not signal worse prognosis in AYA CML patients but it may delay molecular response to imatinib mesylate.


Other data

Title Impact of Additional Chromosomal Aberrations Present at Diagnosis on Outcome of Adolescent and Young Adult Chronic Myeloid Leukemia Patients: A Single Center Experience
Authors El-Ghammaz, Amro ; Hamza, Mohamed Tarif; Said, Rasha Magdy; Moussa, Mohamed Mahmoud; Eissa, Asmaa Mohammed Elsayed; Azzazi, Mohamed Osman
Keywords Additional chromosomal aberrations at diagnosis;Adolescents and young adults;Chronic myeloid leukemia;Prognosis;Treatment response
Issue Date Oct-2019
Publisher Springer
Journal Indian Journal of Hematology and Blood Transfusion 
Volume 35
Start page 683
End page 691
ISSN 0971-4502
DOI 10.1007/s12288-019-01121-w
PubMed ID 31741620

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