Prognostic Impact of Serum Growth Differentiation Factor 15 Level in Acute Myeloid Leukemia Patients

Hegab, Hany Mohamed, Amro El-Ghammaz, El-Razzaz, Mostafa Kamal, Helal, Reham Ali Ali,


Growth differentiation factor 15 (GDF15) plays an important role in cancer pathophysiology and prognosis. However, limited studies analyzed its level and prognostic value in acute myeloid leukemia (AML) patients. This study included 56 adult AML patients. Serum GDF15 level was measured at diagnosis in all patients by enzyme-linked immunosorbent assay. Remission and survival statuses were assessed at 90 days following treatment. GDF15 level was significantly higher in patients than in controls (P < 0.001). GDF15 level correlated positively with age (P < 0.001), hemoglobin level (P = 0.027), and platelet count (P = 0.024). High GDF15 above the median level was associated with inferior OS (P = 0.044) together with high platelet count (P = 0.006) and high bone marrow blast percent (P = 0.038). There was no statistically significant difference between patients with GDF15 above and below the median level regarding DFS (P = 0.881). On multivariate analysis for OS, GDF15 level was an independent risk factor (P = 0.047). In conclusion, serum GDF15 level is significantly elevated in AML patients and high GDF15 level is associated with inferior OS.

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Title Prognostic Impact of Serum Growth Differentiation Factor 15 Level in Acute Myeloid Leukemia Patients
Authors Hegab, Hany Mohamed; Amro El-Ghammaz ; El-Razzaz, Mostafa Kamal; Helal, Reham Ali Ali
Keywords Acute myeloid leukemia;Disease free survival;Growth differentiation factor 15;Overall survival
Issue Date Jan-2021
Publisher Springer
Journal Indian Journal of Hematology and Blood Transfusion 
Volume 37
Start page 37
End page 44
ISSN 0971-4502
DOI 10.1007/s12288-020-01315-7
PubMed ID 33707833

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