Substituted quinolinones. 18. 3-Acetyl-4-methylthioquinolin-2(1H)-one as useful synthon intermediate for synthesis of some new quinolinones
Othman,E.S.;
Abstract
3-Acetyl-4-methylthioquinolin-2(1H)-one (3) has been prepared and its
reactivity towards treatment with different reagents, dilute sulfuric acid, aqueous
sodium hydroxide, and hydrogen peroxide, is described. The reactions of compound 3
with benzylamine, benzaldehyde, DMF-DMA, Vilsmeier-Haack reagent, 2-chloro-3-
formyl-pyridopyrimidone and malononitrile have been carried out under convenient
conditions. Compound 3 underwent heterocyclization reactions with some binucleophiles,
hydrazine, hydroxylamine, urea, thiourea, semicarbazide, and thiosemicarbazide,
furnishing some known five, six, and seven heterocyclic annellated quinolines.
All the new compounds have been characterized using different spectral and analytical
tools.
reactivity towards treatment with different reagents, dilute sulfuric acid, aqueous
sodium hydroxide, and hydrogen peroxide, is described. The reactions of compound 3
with benzylamine, benzaldehyde, DMF-DMA, Vilsmeier-Haack reagent, 2-chloro-3-
formyl-pyridopyrimidone and malononitrile have been carried out under convenient
conditions. Compound 3 underwent heterocyclization reactions with some binucleophiles,
hydrazine, hydroxylamine, urea, thiourea, semicarbazide, and thiosemicarbazide,
furnishing some known five, six, and seven heterocyclic annellated quinolines.
All the new compounds have been characterized using different spectral and analytical
tools.
Other data
Title | Substituted quinolinones. 18. 3-Acetyl-4-methylthioquinolin-2(1H)-one as useful synthon intermediate for synthesis of some new quinolinones | Authors | Othman,E.S. | Issue Date | Mar-2013 | Publisher | Springer | Journal | Research on Chemical Intermediates | Volume | 39 | Issue | 3 | Start page | 1209 | End page | 1225 |
Attached Files
File | Description | Size | Format | Existing users please Login |
---|---|---|---|---|
Hassan2013_Article_SubstitutedQuinolinones183-Ace.pdf | 409.78 kB | Adobe PDF | Request a copy |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.