Tumor microenvironmental plasmacytoid dendritic cells contribute to breast cancer lymph node metastasis via CXCR4/SDF-1 axis
Gadalla, Ramy; Hassan, Hebatallah; Ibrahim, Sherif Abdelaziz; Abdullah, Mahmoud Salah; Gaballah, Ahmed; Greve, Burkhard; El-Deeb, Somaya; El-Shinawi, Mohamed; Mohamed, Mona Mostafa;
Abstract
Plasmacytoid dendritic cells (PDCs) infiltration into breast cancer tissues is associated with poor prognosis. Also, CXCR4 shows compelling evidences to be exploited by cancer cells to migrate to distant sites. The present study investigated lymph node metastasis in the light of PDCs infiltration and the potential cross talk with CXCR4/SDF-1 chemokine axis.
Other data
| Title | Tumor microenvironmental plasmacytoid dendritic cells contribute to breast cancer lymph node metastasis via CXCR4/SDF-1 axis | Authors | Gadalla, Ramy; Hassan, Hebatallah; Ibrahim, Sherif Abdelaziz; Abdullah, Mahmoud Salah; Gaballah, Ahmed ; Greve, Burkhard; El-Deeb, Somaya; El-Shinawi, Mohamed; Mohamed, Mona Mostafa | Keywords | Breast cancer;CXCR4;Lymph node metastasis;Plasmacytoid dendritic cells | Issue Date | Apr-2019 | Journal | Breast cancer research and treatment | ISSN | 0167-6806 1573-7217 |
DOI | 10.1007/s10549-019-05129-8 | PubMed ID | 30632021 |
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