Manipulation of Nanoparticles to Control Multidrug Resistant Bacteria

Abstract

Antibiotic resistance against bacterial microbes is considered as an alarming phenomenon that needs to be addressed urgently to have better therapeutic solutions. Bacterial strains, which gained resistance to antibiotics, are referred to as “Multidrug resistant (MDR) bacteria” [1]. According to Rai et al. [2] the resistant bacteria include both Gram positive and Gram negative species such as multidrug resistant (MDR) Klebsiella pneumonia, vancomycin-resistant Enterococcus faecium (VRE), methicillinresistant Staphylococcus aureus (MRSA), Enterobacter spp. and Pseudomonas aeruginosa. Tanwar et al. [3] defined antibiotic resistance as the insensitivity of the microbe to a compound to which it was previously sensitive. The major problems of microbial resistance is their environmental dissemination and absence of new compounds capable of controlling these microbes [4]. One way of control is by killing these pathogens through overcoming their resistance to most antibiotics. Nanotechnological applications are offering promising solution for this problem through killing these microbes before they acquire resistance [1]. Meanwhile, successful usages of nanotechnology in our life have generated new methods for the development of effective antimicrobial compounds or nanoantimicrobials, capable of overcoming this problem of microbial drug resistance. The development and safe manipulation of these nanoantimicrobials will make a new promise to cure these health problems [2].