Nanoscale poly(acrylic acid)-based hydrogels prepared via a green single-step approach for application as low-viscosity biomimetic fluid tears
Swilem, Ahmed; Elshazly, Amany H M; Hamed, Ashraf A; Hegazy, El-Sayed A; Abd El-Rehim, Hassan A;
Abstract
The present work reports a nanotechnology strategy to prepare a low-viscosity poly(acrylic acid) (PAAc)-based tear substitute with enhanced efficacy and compliance. Specifically, nanogels composed of PAAc and polyvinylpyrrolidone (PVP) were prepared by adapting an ionizing radiation method. For this purpose, different aqueous systems: PVP/PAAc nanoparticulate complexes, PVP/acrylic acid (AAc), N-vinylpyrrolidone (N-VP)/PAAc, and N-VP/AAc were exposed to gamma rays. The dynamic light scattering technique showed that stable nanogels are only produced in a relatively high yield from the PVP/AAc system. Nanogel formation was driven by the hydrogen-bonding complexation between PVP and PAAc (formed in situ) as well as the radiation-induced cross-linking. Transparency, viscosity and mucoadhesiveness of emerged nanogels were optimized by controlling the feed composition and irradiation dose. Furthermore, neutralized nanogels were topically applied in a dry eye model and compared with a PAAc-based commercial tear substitute, namely Vidisic® Gel. The results of Schirmer's test and tear break-up time demonstrated that nanogels prepared from AAc-rich feed solutions at 20 kGy enhanced markedly the dry eye conditions. The histopathological analysis also ensured the competence of PAAc-rich nanogels to completely return the corneal epithelium to its normal state.
Other data
Title | Nanoscale poly(acrylic acid)-based hydrogels prepared via a green single-step approach for application as low-viscosity biomimetic fluid tears | Authors | Swilem, Ahmed ; Elshazly, Amany H M; Hamed, Ashraf A; Hegazy, El-Sayed A; Abd El-Rehim, Hassan A | Keywords | Dry eye;Gamma rays;Mucoadhesion;Nanogel;Poly(acrylic acid);Tear substitute | Issue Date | May-2020 | Journal | Materials science & engineering. C, Materials for biological applications | Volume | 110 | ISSN | 09284931 | DOI | 10.1016/j.msec.2020.110726 | PubMed ID | 32204037 |
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