Synthesis, Spectral Characterization, and In Vitro Biological Evaluation of Some Novel Isoquinolinone‐based Heterocycles as Potential Antitumor Agents
Mohamed Hekal; Sallam, Hanan A.; Abu El-Azm, Fatma;
Abstract
A series of new N-substituted isoquinolin-1,3-dione derivatives were prepared, starting from reaction of (Z)-4-((E)-3-phenylallylidene)isochromane-1,3-dione 4 with different nitrogen nucleophiles. The assigned structures of the prepared compounds were elucidated by spectral methods (IR, 1 H NMR, 13 C NMR, and mass spectroscopy). Some of the newly prepared compounds were tested in vitro against a panel of three human tumor cell lines, namely, hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, and mammary gland breast MCF-7. Also, they were tested as antioxidants. Some of the tested compounds showed very strong cytotoxic activity with respect to the standard.
Other data
Title | Synthesis, Spectral Characterization, and In Vitro Biological Evaluation of Some Novel Isoquinolinone‐based Heterocycles as Potential Antitumor Agents | Authors | Mohamed Hekal ; Sallam, Hanan A.; Abu El-Azm, Fatma | Keywords | RAPID COLORIMETRIC ASSAY;TOPOISOMERASE-II;ANTIOXIDANT;CONDENSATION;DERIVATIVES;SURVIVAL;TOXICITY;KETONES;ANALOGS;GROWTH | Issue Date | 2019 | Publisher | WILEY | Journal | Journal of Heterocyclic Chemistry | Volume | 56 | Issue | 3 | Start page | 795 | End page | 795 | ISSN | 0022-152X 1943-5193 |
DOI | 10.1002/jhet.3448 | Scopus ID | 2-s2.0-85060726633 | Web of science ID | WOS:000461906200006 |
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