New potential antitumor quinazolinones derived from dynamic 2-undecyl benzoxazinone: Synthesis and cytotoxic evaluation
Hekal, Mohamed H.; Abu El-Azm, Fatma;
Abstract
Since the quinazoline and its derivatives have been considered as a novel class of cancer chemotherapeutic agents that show promising activity against different tumors, a new series of 6-iodo-2-undecylquinazolin-4(3H)-ones were prepared via reaction of 6-iodo-2-undecyl-4H-benzoxazin-4-one with nitrogen nucleophiles, namely, primary amines, 4-amino antipyrine, hydrazine hydrate, diamines, ethanol amine, and/or hydrazide derivatives and screened for their antitumor activity in vitro against a panel of three human tumor cell lines namely; hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, and mammary gland breast MCF-7. Compounds 14, 16, and 18 showed remarkable broad spectrum antitumor activity. All compounds were fully characterized by means of IR, MS, and 1H-NMR spectra.
Other data
Title | New potential antitumor quinazolinones derived from dynamic 2-undecyl benzoxazinone: Synthesis and cytotoxic evaluation | Authors | Hekal, Mohamed H. ; Abu El-Azm, Fatma | Keywords | Cytotoxic evaluation;lauroyl chloride;quinazolinone;triazolo[4; 3-a]quinoline-4-carbonitrile;RAPID COLORIMETRIC ASSAY;BIOLOGICAL EVALUATION;ANTICANCER AGENTS;SCHIFF-BASES;DERIVATIVES;DESIGN;QUINAZOLIN-4(3H)-ONES;SULFONAMIDES;INHIBITORS;SURVIVAL | Issue Date | 2018 | Publisher | TAYLOR & FRANCIS INC | Journal | Synthetic Communications | Volume | 48 | Issue | 18 | Start page | 2391 | End page | 2402 | ISSN | 0039-7911 1532-2432 |
DOI | 10.1080/00397911.2018.1490433 | Scopus ID | 2-s2.0-85054842569 | Web of science ID | WOS:000449530700008 |
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