Design, Synthesis, and Evaluation of Some Novel Heterocycles Bearing Pyrazole Moiety as Potential Anticancer Agents
Abdelgawad, Nancy; Hekal, Mohamed H.; Marzouk, Magda I.; Ismail, Mahmoud;
Abstract
1,3-Diphenylpyrazole-4-carboxylaldehyde and o-hydroxyacetophenone were exploited as starting materials for the synthesis of novel substituted chalconated pyrazole derivative. The proclivity of this compound towards carbon and nitrogen nucleophiles such as malononitrile, diethyl malonate, ethyl cyanoacetate, ethyl acetoacetate, semicarbazide, thiosemicarbazide, and hydroxylamine has been investigated. The structures of all synthesized compounds were ascertained by analytical and spectral data. The antitumor activity of the target synthesized compounds was tested against a panel of two human tumor cell lines, namely, hepatocellular carcinoma (liver) HepG2 and mammary gland breast MCF-7.
Other data
| Title | Design, Synthesis, and Evaluation of Some Novel Heterocycles Bearing Pyrazole Moiety as Potential Anticancer Agents | Authors | Abdelgawad, Nancy; Hekal, Mohamed H. ; Marzouk, Magda I.; Ismail, Mahmoud | Keywords | RAPID COLORIMETRIC ASSAY;BIOLOGICAL EVALUATION;IN-VITRO;CHALCONE DERIVATIVES;ANALOGS;INHIBITOR;DISCOVERY;SURVIVAL;GROWTH | Issue Date | 2019 | Publisher | WILEY | Journal | Journal of Heterocyclic Chemistry | Volume | 56 | Issue | 6 | Start page | 1771 | End page | 1779 | ISSN | 0022-152X 1943-5193 |
DOI | 10.1002/jhet.3544 | Scopus ID | 2-s2.0-85064709581 | Web of science ID | WOS:000475943700006 |
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