N'-(1-([1,1'-biphenyl]-4-yl)ethylidene)-2-cyanoacetohydrazide as scaffold for the synthesis of diverse heterocyclic compounds as prospective antitumor and antimicrobial activities
Hamed, Nancy A.; Marzouk, Magda I.; Hekal, Mohamed H.; Ismail, Mahmoud;
Abstract
In this article, the main target was to study the antitumor and antimicrobial efficacy of new heterocycles conjugated with biphenyl moiety in-vitro. This was implemented by utilizing N'-(1-([1,1'-biphenyl]-4-yl)ethylidene)-2-cyanoacetohydrazide 3 as a material for the synthesis of various heterocyclic compounds. Among of them, some compounds were selected and assayed against two antitumor cell lines as (HepG2) and (HCT-116). Conspicuously, the achieved results showed that compounds 6, 13, and 23 possess significant potency against both cancer cell lines. Particularly, compound 13 exhibited a remarkable efficacy, similar to the standard anticancer drug (doxorubicin), against both cancer cell lines. Noteworthy, compound 13 may serve as a potential anticancer therapeutic drug in the future. On the other hand, In-vitro antifungal and antibacterial activities of selected compounds were assayed and the results indicated that the compound 6 exhibited significant potency against Candida albicans, while compounds 6 and 8 displayed spectacular results for the antibacterial study.
Other data
Title | N'-(1-([1,1'-biphenyl]-4-yl)ethylidene)-2-cyanoacetohydrazide as scaffold for the synthesis of diverse heterocyclic compounds as prospective antitumor and antimicrobial activities | Authors | Hamed, Nancy A.; Marzouk, Magda I.; Hekal, Mohamed H. ; Ismail, Mahmoud | Keywords | 4-acetyl biphenyl;antimicrobial activity;antitumor activity;cyanoacetamide derivative;cyanoacetohydrazide;POLYBROMINATED DIPHENYL ETHERS;RAPID COLORIMETRIC ASSAY;ORGANOCHLORINE PESTICIDES;POLYCHLORINATED-BIPHENYLS;DERIVATIVES;ANTIOXIDANT;SURVIVAL;GROWTH | Issue Date | 2019 | Publisher | TAYLOR & FRANCIS INC | Journal | Synthetic Communications | Volume | 49 | Issue | 21 | Start page | 3017 | End page | 3029 | ISSN | 0039-7911 1532-2432 |
DOI | 10.1080/00397911.2019.1655578 | Scopus ID | 2-s2.0-85071309786 | Web of science ID | WOS:000484036000001 |
Attached Files
File | Description | Size | Format | Existing users please Login |
---|---|---|---|---|
8.pdf | 2 MB | Adobe PDF | Request a copy |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.