Utilization of cyanoacetohydrazide and 2-(1,3-dioxoisoindolin-2-yl) acetyl chloride in the synthesis of some novel anti-proliferative heterocyclic compounds
Mohamed Hekal; Ali, Yasmeen M.; Abu El-Azm, Fatma;
Abstract
Owing to its high reactivity and commercial availability, 2-cyanoacetohydrazide can be utilized as a versatile and appropriate intermediate for synthesis of a broad variety of heterocyclic compounds. Thus, 2-cyanoacetohydrazide and 2-(1,3-dioxoisoindolin-2-yl) acetyl chloride were used as starting materials for construction of new heterocyclic compounds bearing 1,3-dioxoisoindoline moiety. The newly synthesized compounds were recognized by elemental analyses and spectral data (IR, 1H-NMR, and 13C-NMR spectra). The synthesized compounds were screened for their anti-proliferative activity against two human epithelial cell lines; breast (MCF-7) and liver (HepG2) as well as to normal fibroblasts (WI-38). The data showed distinctly that compounds 1 and 12 presented promising in-vitro anti-proliferative activity against two cell lines (MCF-7 and HepG2) without harming normal fibroblasts.
Other data
Title | Utilization of cyanoacetohydrazide and 2-(1,3-dioxoisoindolin-2-yl) acetyl chloride in the synthesis of some novel anti-proliferative heterocyclic compounds | Authors | Mohamed Hekal ; Ali, Yasmeen M.; Abu El-Azm, Fatma | Keywords | Benzimidazole derivatives;benzoxazole derivatives;2-cyanoacetohydrazide;2-(1; 3-dioxoisoindolin-2-yl) acetyl chloride;2-pyridone derivatives;RAPID COLORIMETRIC ASSAY;BIOLOGICAL EVALUATION;ANTIMICROBIAL EVALUATION;DERIVATIVES;DESIGN;SERIES;ISOINDOLINE-1,3-DIONE;PHTHALIMIDES;COUMARIN;SURVIVAL | Issue Date | 2020 | Publisher | TAYLOR & FRANCIS INC | Journal | Synthetic Communications | Volume | 50 | Issue | 18 | Start page | 2839 | End page | 2852 | ISSN | 0039-7911 1532-2432 |
DOI | 10.1080/00397911.2020.1786125 | Scopus ID | 2-s2.0-85087627644 | Web of science ID | WOS:000546309600001 |
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