New LC-UV methods for pharmaceutical analysis of novel anti-diabetic combinations
Abdel-Ghany M.; Abdel-Aziz O.; Miriam Farid Ayad Ayad; Tadros M.;
Abstract
© 2017 The Author(s). New, simple, selective, and sensitive liquid chromatography-ultraviolet (LC-UV) methods have been developed and subsequently validated for simultaneous determination of linagliptin-empagliflozin combination and simultaneous determination of alogliptin benzoate-pioglitazone hydrochloride combination. Linearity was found to be acceptable over the concentration ranges of 2-50 μg mL-1, 4-100 μg mL-1, 0.5-25 μg mL-1, and 1-25 μg mL-1 for linagliptin (LNG), empagliflozin (EMG), alogliptin (ALG), and pioglitazone (PGN), respectively. All the methods were applied successfully to the analysis of the pharmaceutical dosage forms. The optimized methods were validated and proved to be robust and accurate for the quality control of the mentioned drugs in their different pharmaceutical dosage forms.
Other data
Title | New LC-UV methods for pharmaceutical analysis of novel anti-diabetic combinations | Authors | Abdel-Ghany M.; Abdel-Aziz O.; Miriam Farid Ayad Ayad ; Tadros M. | Issue Date | 1-Jan-2017 | Journal | Acta Chromatographica | Volume | 29 | Issue | 4 | Start page | 448 | End page | 452 | DOI | 10.1556/1326.2016.00089 | Scopus ID | 2-s2.0-85036660732 |
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