The "J curve" problem revisited: old and new findings
Grassi, Guido; Quarti-Trevano, Fosca; Dell'Oro, Raffaella; Mancia, Giuseppe; lobna hosni ali salem;
Abstract
This paper critically addresses the issue of the "J-curve" paradox--the finding described in studies performed about 30 years ago indicating that treatment-induced systolic blood pressure values below 120 or 125 mm Hg and diastolic blood pressure values below 75 mm Hg are characterized by an increase, rather than a reduction, in the incidence of coronary events. This paper focuses on four major subjects: 1) the benefits of a lower blood pressure target during treatment; 2) the historical background of the "J-curve" phenomenon; 3) the evidence collected in recent clinical trials regarding the existence of a "J-curve" in treated hypertensive patients; and 4) the recent recommendations by the Task Force Committee of the European Society of Hypertension on blood pressure goals to be achieved during treatment.
Other data
Title | The "J curve" problem revisited: old and new findings | Authors | Grassi, Guido; Quarti-Trevano, Fosca; Dell'Oro, Raffaella; Mancia, Giuseppe; lobna hosni ali salem | Issue Date | Aug-2010 | Journal | Current hypertension reports | ISSN | 1522-6417 1534-3111 |
DOI | 10.1007/s11906-010-0121-7 | PubMed ID | 20524090 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.