A potential immunological diagnostic marker for acute myeloid leukemia: the expression of the immune checkpoint B and T lymphocyte attenuator
Radwan, Sara; Kamal, Amany; Nabih, N.A.; Elkholy, Amal; Elleboudy, Nooran;
Abstract
Introduction Provided the physiologic tumor suppressive
role a healthy immune system has, diagnosis of cancer is
sometimes also regarded as a diagnosis of an immune
dysfunction. Immunoediting refers to the change of immune
system response from tumor protection to tumor promotion,
favoring the growth of poorly immunogenic clones that have
the ability to evade the immune response. Among the
mechanisms by which the tumor cells bypass the immune
system is immune checkpoints. Which are immune inhibitory
pathways responsible for self-tolerance and limiting selftissue damage by controlling the magnitude and duration of
the immune reaction.
Objective Studying the expression of the novel immune
checkpoint BTLA in patients with AML and evaluate its
clinicopathological and diagnostic significance.
Patients and methods We investigated the expression of
BTLA gene in 60 AML cases and 15 healthy controls using
RT-PCR.
Results The current study revealed that significant up
regulation of BTLA mRNA expression in AML patients as in
comparison with the control group (P=0.024).
Discussion These results provide a basis for the perception
that BTLA upregulation is involved in inhibition of antitumor
immunity and that high BTLA expression level can be made
use of as a diagnostic marker in patients with AML.
role a healthy immune system has, diagnosis of cancer is
sometimes also regarded as a diagnosis of an immune
dysfunction. Immunoediting refers to the change of immune
system response from tumor protection to tumor promotion,
favoring the growth of poorly immunogenic clones that have
the ability to evade the immune response. Among the
mechanisms by which the tumor cells bypass the immune
system is immune checkpoints. Which are immune inhibitory
pathways responsible for self-tolerance and limiting selftissue damage by controlling the magnitude and duration of
the immune reaction.
Objective Studying the expression of the novel immune
checkpoint BTLA in patients with AML and evaluate its
clinicopathological and diagnostic significance.
Patients and methods We investigated the expression of
BTLA gene in 60 AML cases and 15 healthy controls using
RT-PCR.
Results The current study revealed that significant up
regulation of BTLA mRNA expression in AML patients as in
comparison with the control group (P=0.024).
Discussion These results provide a basis for the perception
that BTLA upregulation is involved in inhibition of antitumor
immunity and that high BTLA expression level can be made
use of as a diagnostic marker in patients with AML.
Other data
Title | A potential immunological diagnostic marker for acute myeloid leukemia: the expression of the immune checkpoint B and T lymphocyte attenuator | Authors | Radwan, Sara ; Kamal, Amany ; Nabih, N.A.; Elkholy, Amal ; Elleboudy, Nooran | Keywords | acute myeloid leukemia;B and T lymphocyte attenuator;cancer immunology;immune checkpoints;T cells;CANCER;CELLS;BLOCKADE;BTLA | Issue Date | 29-Dec-2020 | Publisher | WOLTERS KLUWER MEDKNOW PUBLICATIONS | Journal | THE EGYPTIAN JOURNAL OF HAEMATOLOGY | Volume | 45 | Issue | 2 | Start page | 92 | End page | 96 | ISSN | 1110-1067 | DOI | 10.4103/ejh.ejh_13_20 | Web of science ID | WOS:000606858700006 |
Attached Files
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A potential immunological diagnostic marker for acute myeloid.pdf | 1.05 MB | Unknown | View/Open | |
A potential immunological diagnostic marker for acute myeloid.pdf | 1.05 MB | Unknown | View/Open |
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