Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis
Kassem, Dina; Kamal, Mohamed;
Abstract
Corona virus disease 2019 (COVID-19) is a global public health crisis. The high infectivity of the disease even from non-symptomatic infected patients, together with the lack of a definitive cure or preventive measures are all responsible for disease outbreak. The severity of COVID-19 seems to be mostly dependent on the patients’ own immune response. The over-activation of the immune system in an attempt to kill the virus, can cause a “cytokine storm” which in turn can induce acute respiratory distress syndrome (ARDS), as well as multi-organ damage, and ultimately may lead to death. Thus, harnessing the immunomodulatory properties of mesenchymal stem cells (MSCs) to ameliorate that cytokine-storm can indeed provide a golden key for the treatment of COVID-19 patients, especially severe cases. In fact, MSCs transplantation can improve the overall outcome of COVID-19 patients via multiple mechanisms; first through their immunomodulatory effects which will help to regulate the infected patient inflammatory response, second via promoting tissue-repair and regeneration, and third through their antifibrotic effects. All these mechanisms will interplay and intervene together to enhance lung-repair and protect various organs from any damage resulting from exaggerated immune-response. A therapeutic modality which provides all these mechanisms undoubtedly hold a strong potential to help COVID-19 patients even those with the worst condition to hopefully survive and recover.
Other data
Title | Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis | Authors | Kassem, Dina ; Kamal, Mohamed | Keywords | corona virus;COVID-19;cytokine storm;exosomes;extracellular vesicles;immunomodulation;mesenchymal stem cells;SARS-CoV-2 | Issue Date | 30-Sep-2020 | Publisher | FRONTIERS MEDIA SA | Journal | Frontiers in Cell and Developmental Biology | ISSN | 2296-634X | DOI | 10.3389/fcell.2020.587866 | PubMed ID | 33102489 | Scopus ID | 2-s2.0-85092714608 | Web of science ID | WOS:000579142900001 |
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