Effect of Pentoxifylline on Organ Dysfunction and Mortality in Severe Sepsis

SOBHY, AMR;

Abstract


Background:
Sepsis and infection are among the leading causes of death world-wide. The annual burden of sepsis in high-income countries is rising with a
mortality rate of 40% and 90% of the worldwide deaths from pneumonia, meningitis or other infections occur in less developed countries. This
study was performed to evaluate the therapeutic efficacy of pentoxifylline as an adjuvant therapy in septic patients and its effect on multiple organ
dysfunction and mortality in septic patients.
Methods:
This randomized, double-blinded prospective study was conducted from October 2017 to November 2018, which included a total sample size of 52
cases of septic patients. Organ dysfunction was used as a primary outcome with proposed large effect size ((0.8) and alfa =0.05 and power=0.80,
so, 26 cases were needed in each group). Secondary outcomes were inflammatory markers C-Reactive Protein (CRP) and pro-calcitonin, duration
of hospital stay, need for hemodialysis, need for vasopressor & inotropes, need for mechanical ventilation and 28 days survival.
Results:
Fifty-two patients with sepsis were divided in 1: 1 ratio to receive pentoxifylline or not. The average age of the included patients was almost 53
years, chest disorders were the main cause of sepsis in both groups. There were no statistically significant differences between both groups in terms
of Sequential Organ Failure Assessment (SOFA) score, lactate level, CRP level and pro-calcitonin level. As regards secondary outcomes, there
were no statistically significant differences between study’s groups in terms of length of hospital stay (p =0.707), need for hemodialysis (p =0.541),
need for vasopressor & inotropes (p =0.249), need for mechanical ventilation (p =0.703), and 28 days survival (p =0.5).
Conclusion:
We concluded that pentoxifylline as an adjuvant therapy in septic patients had no significant influence on multiple organ dysfunction and
mortality.


Other data

Title Effect of Pentoxifylline on Organ Dysfunction and Mortality in Severe Sepsis
Authors SOBHY, AMR 
Keywords CRP;SOFA;Sepsis;Procalcitonin;Mortality;Pentoxifylline
Issue Date 22-Feb-2020
Journal The Open Anesthesia Journal 
Volume 14
Start page 14
End page 21
DOI 10.2174/2589645802014010014

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