Potentiometric Carbon Quantum Dots-Based Screen-Printed Arrays for Nano-Tracing Gemifloxacin as a Model Fluoroquinolone Implicated in Antimicrobial Resistance
Mona H. Abdelrahman; Nermine Victor Fares; Nancy Magdy; Miriam Farid Ayad Ayad; Trabik, YA;
Abstract
Antimicrobial resistance (AMR) is a neglected issue that poses a serious global threat
to public health, causing long-term negative consequences at both humanitarian and economic
levels. Herein, we report an unprecedented economic fabrication method of seven potentiometric
screen-printed sensors for the ultra-trace determination of gemifloxacin (GEMI) as a model of the
fluoroquinolones antibiotics deeply involved in the growing AMR problem. Sensors were constructed
by depositing homemade carbon ink on a recycled X-ray sheet, patterned using stencils printed with
an office printer in simple, cost-effective steps requiring no sophisticated equipment. Four sensors
were modified using carbon quantum dots (CQDs) synthesized from dextrose through a single-step
method. Sensors exhibited a linear response in the concentration ranges 10−5−10−2 M (sensors 1,
3 and 4), 10−6−10−3 M (sensor 2) and 10−6−10−2 M (sensors 5, 6 and 7). LOD allowed tracing
of the target drug at a nano-molar level down to 210 nM. GEMI was successfully determined in
pharmaceutical formulations and different water samples without any pretreatment steps with
satisfactory recovery (96.93–105.28% with SD values <3). All sensors revealed a long lifetime of up to
several months and are considered promising tools for monitoring water quality and efficiency of
water treatment measures.
to public health, causing long-term negative consequences at both humanitarian and economic
levels. Herein, we report an unprecedented economic fabrication method of seven potentiometric
screen-printed sensors for the ultra-trace determination of gemifloxacin (GEMI) as a model of the
fluoroquinolones antibiotics deeply involved in the growing AMR problem. Sensors were constructed
by depositing homemade carbon ink on a recycled X-ray sheet, patterned using stencils printed with
an office printer in simple, cost-effective steps requiring no sophisticated equipment. Four sensors
were modified using carbon quantum dots (CQDs) synthesized from dextrose through a single-step
method. Sensors exhibited a linear response in the concentration ranges 10−5−10−2 M (sensors 1,
3 and 4), 10−6−10−3 M (sensor 2) and 10−6−10−2 M (sensors 5, 6 and 7). LOD allowed tracing
of the target drug at a nano-molar level down to 210 nM. GEMI was successfully determined in
pharmaceutical formulations and different water samples without any pretreatment steps with
satisfactory recovery (96.93–105.28% with SD values <3). All sensors revealed a long lifetime of up to
several months and are considered promising tools for monitoring water quality and efficiency of
water treatment measures.
Other data
Title | Potentiometric Carbon Quantum Dots-Based Screen-Printed Arrays for Nano-Tracing Gemifloxacin as a Model Fluoroquinolone Implicated in Antimicrobial Resistance | Authors | Mona H. Abdelrahman; Nermine Victor Fares ; Nancy Magdy; Miriam Farid Ayad Ayad ; Trabik, YA | Keywords | antimicrobial resistance;gemifloxacin mesylate;screen-printed potentiometric sensors;carbon quantum dots;water samples | Issue Date | 31-Dec-2020 | Publisher | MDPI | Journal | Chemosensors | Volume | 9 | Issue | 9 | Start page | 8 | ISSN | 2227-9040 | DOI | 10.3390/chemosensors9010008 | Scopus ID | 2-s2.0-85100140548 | Web of science ID | WOS:000609988000001 |
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