Association Between Interleukin-8 Levels in Bronchoalveolar Lavage Fluid and its Correlation with Severity in Children With Bronchiectasis

Abstract

Bronchiectasis (BE) is a complex chronic respiratory condition characterized by a “vicious cycle” of infection and dysregulated airway inflammation resulting in progressive decline in lung function associated with significant morbidity in children that extend beyond the respiratory system and include cardiac and psychological effects. Chronic neutrophil-dominant airway inflammation is a key feature of bronchiectasis and activated neutrophils represent a key component of the “vicious cycle” of lung damage through the release of their harmful cellular contents, particularly, cell-derived proteases and reactive oxygen species.