Procollagen 111-N-Peptide and Some Elements in Thyroid Dysfunction

Abstract

The. present study is concerned with the influence of thyroid dysfunction on the serum procollagen III-N-peptide levels in cases of hyperthyroidism and hypothyroidism.. In addition, three essential elements e.g., calcium, magnesium and total iron were also determined in the same patients. Correlation coefficients (r), between the different studied parameters were also studied. Preliminary analysis of serum levels of glucose, AST, ALT, total protein, albumin and A/G was carried out to exclude subjects with diseases other than thyroid disorders, such as diabetes mellitus or liver diseases. This study was carried out on 35 patients with hyperthyroidism (Gr.II), 30 patients with hypothyroidism (Gr.III), and 12 normal healthy subjects as a reference control group (Gr. I). Results: This study revealethat serum procollagen lii and blood total iron levels manifested a significant sharp •elevation m hyperthyroid group, while they were reduced significantly m hypothyroid patients. A significant increase in serum calcium concentration is reported in hyperthyroid patients, while it was non

significantly changed in hypothyroid patients. On the contrary, serum magnesium was significantly reduced in hyperthyroid patients, while it was increased significantly in hypothyroidism. Two negative correlations were fo'und: a) P III NP vs TSH. b) T4 vs Ca in hyperthyroid and hypothyroid patients. Also, a positive .correlation was found between T3 and total iron in hyperthyroid patients. Conclusion: This work confirms that thyroid hormones have a great influence upon collagen III synthesis i.e. procollagen III NP whih in turn is considered as a direct marker of connective tissue response. Thus, P III NP is confirmed to be a valuab.le dependable marker that . reflects the hyperthyroid state.