Comparative Study between Efficacy & Safety of Silodosin, Tadalafil and Silodosin plus Tadalafil as a Medical Expulsive Therapy for Distal Ureteral Stones

Abstract

rolithiasis is one of the commonest urinary tract diseases. Ureteral stones account for 20% of urolithiasis, and 70% of ureteral stones are located in the lower third of the ureter. Conservative management strategies such as observation or medical expulsive therapy using alpha-1 blockers and PDE5 inhibitors to facilitate passage of ureteral stones have commonly used during the recent years. The mechanism of action of alpha-1 blockers is blockage of α1-adrenergic receptors in the ureteric smooth muscle cells results in relaxation of the ureteric smooth muscles and, therefore, causes ureteric lumen dilatation which results in facilitation of stone expulsion.