A study on the Potential Protective Effect of Wogonin Against Cisplatin-Induced Nephrotoxicity in Rats
Alaa Mahdy Taha El-Said Badawy;
Abstract
Abstract
Cisplatin, a platinum chemotherapeutic agent, is used in a diversity of malignancies; however, the excessive nephrotoxicity following cisplatin treatment is the dose-limiting destructive reaction. In fact, numerous mechanisms are anticipated to induce cisplatin nephrotoxicity. Indeed, the mechanisms underlying cisplatin-mediated nephrotoxicity are not absolutely understood. The current study was designed to explore the possible nephroprotective impact of wogonin, a forceful anti-oxidant, anti-inflammatory, and anti-tumor agent, in a rat model of cisplatin-induced renal injury.
Cisplatin, a platinum chemotherapeutic agent, is used in a diversity of malignancies; however, the excessive nephrotoxicity following cisplatin treatment is the dose-limiting destructive reaction. In fact, numerous mechanisms are anticipated to induce cisplatin nephrotoxicity. Indeed, the mechanisms underlying cisplatin-mediated nephrotoxicity are not absolutely understood. The current study was designed to explore the possible nephroprotective impact of wogonin, a forceful anti-oxidant, anti-inflammatory, and anti-tumor agent, in a rat model of cisplatin-induced renal injury.
Other data
| Title | A study on the Potential Protective Effect of Wogonin Against Cisplatin-Induced Nephrotoxicity in Rats | Other Titles | دراسة التأثير الوقائى المحتمل من وجونين ضد السمية الكلوية التى يسببها سيسبلاتين فى الجرذان | Authors | Alaa Mahdy Taha El-Said Badawy | Issue Date | 2019 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| CC2338.pdf | 356.01 kB | Adobe PDF | View/Open |
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