Retrospective Analysis of the Prognostic Factors that Influence Treatment Response and Survival of Patients with Cancer of Unknown Primary

Abstract

ancer of Unknown Primary (CUP) is a heterogeneous group of metastatic cancers for which the primary site of origin at time of diagnosis after fulfilling routine diagnostic tools. CUP make up 3–5% of total cancer diagnoses worldwide. In Egypt it is around 6.1%in males and 5.5% in females. CUP has mainly poor prognosis with aggressive behavior; its overall survival varies between (6–9 months) with an average of 7 months. Several studies found that many factors were proved to impact the survival and treatment outcome including: age, gender, performance status, comorbidities, serum albumin level, serum alkaline phosphatase level, and smoking.