Effect of Lacosamide on cognitive dysfunction in streptozotocin-induced Alzheimer rat model

Abstract

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder. It is characterized by memory loss and cognition impairment accompanied by personality changes and abnormal behavior. AD is the most common cause of dementia AD dementia accounts for as many as 60 - 70% of senile dementia cases according to the world health organization . Many factors contribute to AD pathology development including genetics, environment, toxic substances exposure, age, depression, neurotrophic factors deficiency, brain trauma are among these factors. The key neuropathological features of AD include deposition of extracellular amyloid plaque and intracellular neurofibrillary tangles (NFT) starting in hippocampus then spreading to cortical grey mater.