Interleukin-6 In Urine And Serum Of Patients With Urinary Tract Infection

Abstract

Urinary tract infection is defined as the presence of actively multiplying organisms within the urinary tract. This study was carried out to estimate the levels of urinary and serum IL-6 in patients with UTI either in lower or upper forms . 40 cases {7 males and 33 females) were clinically and laboratory investigated for symptoms and signs of UTI. 10 cases of apparently healthy pe"rsons. have been taken also as controls. For every case and control the following investigation was done:.. • Complete urine analysis • Quantitative estimation of bacteriuria{Bacterial Count) • Urine cultures • Blood cultures. • Estimation of the level of urinary and serum IL-6 by ELISA technique . Analysing the results obtained in this study we found that, Gram - negative bacilli were the most common isolated causative organism especially E.coli which represent (77.5%) of cases. Also blood cultures illustrated that 6 bacteremic cases could be detected from total 40 cases subjected to blood cultures. The isolated orgamsm was• E.coli, while no anaerobic organism could be detected. In general, IL-6 in serum and urine was significantly higher in cases with UTI than control group, meanwhile the level of urinary IL-6 in patients with UTI was found to be of a highly statistically significant value in both foirns of urinaiy tract infection''tfian controls, which indicate that IL -6 is secreted locally due to infection and it could be considered as a significant sign of UTI. On the other hand serum IL-6 was detected with significant value in only upper form of UTI. The level of .serum and urine IL-6 showed to be elevated in patients with Gram - negative bacilli infection and the highest production of IL-6 either in urine or serum was found to be accompanying Proteus infection.