Evaluation of Serum Hepcidin as a Potential Marker in Obese anemic patients

Abstract

Hepcidin is well known as iron-regulatory hormone. Generally, it causes a decrease in serum iron Hepcidin is a hormone secreted in response to iron loading and inflammation. The production of hepcidin is regulated by iron, so that more hepcidin is produced by hepatocytes when iron is abundant, limiting further iron absorption and release from stores. When iron is deficient, hepatocytes produce less or no hepcidin, allowing more iron to enter plasma Evidence, in fact, has been provided for a tight direct correlation between hepcidin expression and some cytokines such as interleukin-6(IL-6) and C-reactive protein that are increased in obesity. To strengthen the possible link between the poor iron status of obesity and hepcidin. 2- The purpose of this study was to asses serum hepcidin in obese anemic patients. To identify the presence or absence of a relationship between abnormal serum hepcidin level and deranged iron homeostasis in obese anemic patients.