Assessment of Vitamin D Level in Newly Diagnosed Multiple Myeloma Patients and Patients in Remission

Abstract

Background: Vitamin D (D represents D2, D3, or both) is a secosterol produced endogenously in the skin from sun exposure or obtained from foods that naturally contain vitamin D, including cod liver oil and fatty fish (eg, salmon, mackerel, and tuna); UV-irradiated mushrooms; foods fortified with vitamin D; and supplements. Objectives: The aim of the present study is to compare between vitamin D level in newly diagnosed patients with Multiple Myeloma and patients in remission. Patients and Methods: This was a Case Control study performed at Hematology Bone marrow transplantation ward and Hematology outpatient clinic at Ain shams University Hospital from July 2018 to July 2019. A total of 40 patients were enrolled in the study, 20 are newly diagnosed Multiple Myeloma patients and 20 patients completed Treatment. A total of 20 (M/F: 11/9) age and sex matched healthy volunteers, with negative history of any other malignancy were also included in the study. The aim of the present study is to compare between vitamin D level in newly diagnosed patients with Multiple Myeloma and patients in remission. Results: In Newly diagnosed group; 25% of subjects had vitamin D deficiency, 55% of subjects had vitamin D insufficiency and only 20% had sufficient levels. In MM patients received treatment; No patient had vitamin D deficiency, 65% had vitamin D insufficiency and only 35% had sufficient levels. Conclusion: We found high incidence of vitamin d insufficiency in newly diagnosed MM patients and patient received treatment. We did not detect differences in skeletal morbidity between patients who had vitamin D deficiency and those who did not at time of diagnosis. There was no significant correlation between vitamin D levels and Ca, LDH and B2microglobulin in the two groups. We found higher creatinine levels in newly diagnosed patients with Low vitamin D. We did not demonstrate a relationship between R-ISS stage and vitamin D status.