Lipidomic Study on the Effect of Eclipta prostrata and Bauhinia retusa on Experimentally Induced Fatty liver in Rats

Abstract

onalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide. The major characteristic of NAFLD is the metabolic syndrome dyslipidemia. It is generally related to a high calorie intake and sedentary life style. While liver biopsy remains the gold standard for diagnosis, staging and prognosis for the NAFLD spectrum disorders, this invasive procedure is not recommended due to high risks and cost. Advanced diagnostic approach are demanded for novel management strategies for NAFLD. Lipidomics, a novel technique, refers to the quantitative determination of all lipids in a given cellular system at a certain time point. Due to its sensitivity and specificity, mass spectrometry (MS) is the underlying technology of choice for simultaneous determination of large sets of lipids. Lipidomics of plasma and urine became a potential candidate for metabolic biomarkers in several metabolic diseases as NAFLD.