The Value of Mean Platelet Volume in Diagnosing Non Alcoholic Fatty Liver Disease in Diabetic and Non-Diabetic Patients

Abstract

he ability to determine the degree of the liver steatosis and fibrosis as well as to predict the progression of disease is essential in the management of patients with NAFLD. A liver biopsy has been used as a gold standard for this purpose over many years. However, its invasive nature, high cost, and risk for development of severe complications (bleeding in particular) resulted in the development of noninvasive tests. These tests consist of different scores derived from various combinations of serologic markers as well as noninvasive imaging modalities. In this case control comparative study we wanted to measure the MPV in 100 Egyptian adults with nonalcoholic fatty liver disease (NAFLD) in both diabetic and non-diabetic patients and 50 apparently healthy adults' age and sex matched as a control group. We found that; 1. Platelet count (PC) was significant lower in NAFLD cases compered to control. 2. MPV in NAFLD was significantly higher in NAFLD cases than control group.